Myocardial regeneration therapy for ischemic cardiomyopathy with cyclin A2
نویسندگان
چکیده
منابع مشابه
Therapeutic delivery of cyclin A2 induces myocardial regeneration and enhances cardiac function in ischemic heart failure.
BACKGROUND Heart failure is a global health concern. As a novel therapeutic strategy, the induction of endogenous myocardial regeneration was investigated by initiating cardiomyocyte mitosis by expressing the cell cycle regulator cyclin A2. METHODS AND RESULTS Lewis rats underwent left anterior descending coronary artery ligation followed by peri-infarct intramyocardial delivery of adenoviral...
متن کاملCyclin A2 induces cardiac regeneration after myocardial infarction and prevents heart failure.
Mammalian myocardial infarction is typically followed by scar formation with eventual ventricular dilation and heart failure. Here we present a novel model system in which mice constitutively expressing cyclin A2 in the myocardium elicit a regenerative response after infarction and exhibit significantly limited ventricular dilation with sustained and remarkably enhanced cardiac function. New ca...
متن کاملCyclin A2 Induces Cardiac Regeneration After Myocardial Infarction and Prevents Heart
Mammalian myocardial infarction is typically followed by scar formation with eventual ventricular dilation and heart failure. Here we present a novel model system in which mice constitutively expressing cyclin A2 in the myocardium elicit a regenerative response after infarction and exhibit significantly limited ventricular dilation with sustained and remarkably enhanced cardiac function. New ca...
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Cell therapy has tremendous potential for the damaged heart, which has limited self-renewing capability. Bone marrow (BM) cells are attractive for cell therapy, as they contain diverse stem and progenitor cell populations that can give rise to various cell types, including cardiomyocytes, endothelial cells, and smooth muscle cells. Studies have shown BM cells to be safe and efficacious in the t...
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Background Low dose dobutamine stress magnetic resonance imaging (LDDSMR) is a widely accepted technique for assessment of hibernating myocardium in patients with ischemic cardiomyopathy (ICMP). It is particularly helpful in patients with intermediate transmurality of scar where prediction of functional recovery by late gadolinium enhancement imaging (LGE) alone is difficult. Analysis of LDDSMR...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 2007
ISSN: 0022-5223
DOI: 10.1016/j.jtcvs.2006.07.057